Product Name Carboxygel Product Code 1703-xx Bead size 60-160µm Agarose concentration 4% Spacer arm 10 atoms, hydrophilic Flow rate 1000cm/h* Cleaning 0.15M NaOH Storage conditions 20% Ethanol, 2-8°C Functional group to attach NH2- of small molecule Reactive group concentration 30-35 µmoles Temperature stability range ambient Functional Ligand COOH Blocking agents Mercaptoethanol, ethanolamine Coupling in organic solvents yes Coupling in a packed column no pH stability range 2-13 Coupling conditions pH 4-6, 0-22°C, 1-16 hours Chemical stability 0.1M NaOH, 8M Urea, 6M Guanidine, Ethanol, and Common Buffers Drug master file With U.S. Food & Drug Administration

Carboxygel effectively couples peptides and small ligands. It is primarily recommended for the linkage of small ligands where long hydrophilic spacer arms are needed to allow access of the protein to the coupled ligand. Carboxygel possesses a high substitution and coupling efficiency. Due to the potential for intermolecular polymerization in a side reaction, coupling of large proteins is better accomplished with Actigel ALD than with Aminogel or Carboxygel. The medium is capable of coupling in both aqueous solution and organic solvent.

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