ストラトスフェア・レジン アプリケーション別選択ガイド I

アミド合成

Leaving Group	Starting Material	Resin	Cleavage Conditions
R1-CONH2	-CO2H	PL-MBHA	Strong acid
		PL-Rink	Moderate Acid
		PL-HMBA	Ammonolysis
		PL-Oxime
R1-CONH-R2	-CO2H	PL-HMBA	R2NH2
		PL-Oxime
		PL-HTP
		PL-SABu PL-SABz	(i) CH2N2 or BrCH2CN (ii) R2NH2
R1-CONR2R3	-CO2H	PL-SABu PL-SABz	(i) CH2N2 or BrCH2CN (ii) R2R3NH
		PL-HTP	R2R3NH
R1NHCO-R2	-NH2	PL-FMP	Moderate acid
		PL-FDMP
		PL-ICHO